G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

[Image: see text] G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T. brucei, L. major, and P. falcipa...

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Detalles Bibliográficos
Publicado en:J Med Chem
Main Authors: Belmonte-Reche, Efres, Martínez-García, Marta, Guédin, Aurore, Zuffo, Michela, Arévalo-Ruiz, Matilde, Doria, Filippo, Campos-Salinas, Jenny, Maynadier, Marjorie, López-Rubio, José Juan, Freccero, Mauro, Mergny, Jean-Louis, Pérez-Victoria, José María, Morales, Juan Carlos
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2018
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148440/
https://ncbi.nlm.nih.gov/pubmed/29323491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01672
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