G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

[Image: see text] G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T. brucei, L. major, and P. falcipa...

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Publicat a:J Med Chem
Autors principals: Belmonte-Reche, Efres, Martínez-García, Marta, Guédin, Aurore, Zuffo, Michela, Arévalo-Ruiz, Matilde, Doria, Filippo, Campos-Salinas, Jenny, Maynadier, Marjorie, López-Rubio, José Juan, Freccero, Mauro, Mergny, Jean-Louis, Pérez-Victoria, José María, Morales, Juan Carlos
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148440/
https://ncbi.nlm.nih.gov/pubmed/29323491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01672
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