G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

[Image: see text] G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T. brucei, L. major, and P. falcipa...

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發表在:J Med Chem
Main Authors: Belmonte-Reche, Efres, Martínez-García, Marta, Guédin, Aurore, Zuffo, Michela, Arévalo-Ruiz, Matilde, Doria, Filippo, Campos-Salinas, Jenny, Maynadier, Marjorie, López-Rubio, José Juan, Freccero, Mauro, Mergny, Jean-Louis, Pérez-Victoria, José María, Morales, Juan Carlos
格式: Artigo
語言:Inglês
出版: American Chemical Society 2018
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148440/
https://ncbi.nlm.nih.gov/pubmed/29323491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01672
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