Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus

Glycogen synthase kinase-3 (GSK-3) is ubiquitously expressed throughout the brain and involved in vital molecular pathways such as cell survival and synaptic reorganization and has emerged as a potential drug target for brain diseases. A causal role for GSK-3, in particular the brain-enriched GSK-3β...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Engel, Tobias, Gómez-Sintes, Raquel, Alves, Mariana, Jimenez-Mateos, Eva M., Fernández-Nogales, Marta, Sanz-Rodriguez, Amaya, Morgan, James, Beamer, Edward, Rodríguez-Matellán, Alberto, Dunleavy, Mark, Sano, Takanori, Avila, Jesus, Medina, Miguel, Hernandez, Felix, Lucas, José J., Henshall, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147910/
https://ncbi.nlm.nih.gov/pubmed/30237424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0963-5
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