Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication

Epstein-Barr virus (EBV) ZEBRA protein activates the EBV lytic cycle. Cellular AP-1 proteins with alanine-to-serine [AP-1(A/S)] substitutions homologous to ZEBRA(S186) assume some functions of EBV ZEBRA. These AP-1(A/S) mutants bind methylated EBV DNA and activate expression of some EBV genes. Here,...

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Pubblicato in:J Virol
Autori principali: Lyons, Danielle E., Yu, Kuan-Ping, Vander Heiden, Jason A., Heston, Lee, Dittmer, Dirk P., El-Guindy, Ayman, Miller, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146812/
https://ncbi.nlm.nih.gov/pubmed/30021895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01062-18
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