A Noncanonical Basic Motif of Epstein-Barr Virus ZEBRA Protein Facilitates Recognition of Methylated DNA, High-Affinity DNA Binding, and Lytic Activation

The pathogenesis of Epstein-Barr virus (EBV) infection, including development of lymphomas and carcinomas, is dependent on the ability of the virus to transit from latency to the lytic phase. This conversion, and ultimately disease development, depends on the molecular switch protein, ZEBRA, a viral...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Weber, Erin, Buzovetsky, Olga, Heston, Lee, Yu, Kuan-Ping, Knecht, Kirsten M., El-Guindy, Ayman, Miller, George, Xiong, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600195/
https://ncbi.nlm.nih.gov/pubmed/31068430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00724-19
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