Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection

Elucidating the structural basis of antibody (Ab) gene usage and affinity maturation of vaccine-induced Abs can inform the design of immunogens for inducing desired Ab responses in HIV vaccine development. Analyses of monoclonal Abs (MAbs) encoded by the same immunoglobulin genes at different stages...

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Bibliographic Details
Published in:J Virol
Main Authors: Chan, Kun-Wei, Pan, Ruimin, Costa, Matthew, Gorny, Miroslaw K., Wang, Shixia, Lu, Shan, Kong, Xiang-Peng
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146712/
https://ncbi.nlm.nih.gov/pubmed/29997214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00641-18
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