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Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV
Data from the RV144 HIV vaccine trial indicated that gp120 V2 antibodies were associated with a lower risk of infection; thus, the mapping of V2 epitopes can contribute to the design of an effective HIV vaccine. We solved the crystal structure of human monoclonal antibody (MAb) 2158, which targets a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3993739/ https://ncbi.nlm.nih.gov/pubmed/24478429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03153-13 |
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