Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV

Data from the RV144 HIV vaccine trial indicated that gp120 V2 antibodies were associated with a lower risk of infection; thus, the mapping of V2 epitopes can contribute to the design of an effective HIV vaccine. We solved the crystal structure of human monoclonal antibody (MAb) 2158, which targets a...

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Bibliographic Details
Main Authors: Spurrier, Brett, Sampson, Jared, Gorny, Miroslaw K., Zolla-Pazner, Susan, Kong, Xiang-Peng
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993739/
https://ncbi.nlm.nih.gov/pubmed/24478429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03153-13
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