Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation

BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrated that sphingosine-1-phosphate (S1P), the produc...

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Pubblicato in:Endocrinol Metab (Seoul)
Autori principali: Hong, Seok-Woo, Lee, Jinmi, Kwon, Hyemi, Park, Se Eun, Rhee, Eun-Jung, Park, Cheol-Young, Oh, Ki-Won, Park, Sung-Woo, Lee, Won-Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Endocrine Society 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145960/
https://ncbi.nlm.nih.gov/pubmed/30229580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3803/EnM.2018.33.3.403
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