Denervation-activated STAT3-IL6 signaling in fibro-adipogenic progenitors promotes myofibers atrophy and fibrosis

Fibro-Adipogenic Progenitors (FAPs) are typically activated in response to muscle injury, and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to promote muscle repair. We found that denervation causes progressive accumulation of FAPs, without concomitant infiltratio...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Madaro, Luca, Passafaro, Magda, Sala, David, Etxaniz, Usue, Lugarini, Francesca, Proietti, Daisy, Alfonsi, Maria Vittoria, Nicoletti, Chiara, Gatto, Sole, De Bardi, Marco, Rojas-García, Ricardo, Giordani, Lorenzo, Marinelli, Sara, Pagliarini, Vittoria, Sette, Claudio, Sacco, Alessandra, Puri, Pier Lorenzo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145844/
https://ncbi.nlm.nih.gov/pubmed/30050118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0151-y
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