Denervation-activated STAT3-IL6 signaling in fibro-adipogenic progenitors promotes myofibers atrophy and fibrosis

Fibro-Adipogenic Progenitors (FAPs) are typically activated in response to muscle injury, and establish functional interactions with inflammatory and muscle stem cells (MuSCs) to promote muscle repair. We found that denervation causes progressive accumulation of FAPs, without concomitant infiltratio...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Cell Biol
Κύριοι συγγραφείς: Madaro, Luca, Passafaro, Magda, Sala, David, Etxaniz, Usue, Lugarini, Francesca, Proietti, Daisy, Alfonsi, Maria Vittoria, Nicoletti, Chiara, Gatto, Sole, De Bardi, Marco, Rojas-García, Ricardo, Giordani, Lorenzo, Marinelli, Sara, Pagliarini, Vittoria, Sette, Claudio, Sacco, Alessandra, Puri, Pier Lorenzo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145844/
https://ncbi.nlm.nih.gov/pubmed/30050118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0151-y
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