C-terminal end-directed protein elimination by CRL2 ubiquitin ligases

The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant proteins. How miscellaneous defective proteins are specifically eliminated and which molecular characteristics direct them for removal are fundamental questions. We reveal a mechanism, D...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lin, Hsiu-Chuan, Yehf, Chi-Wei, Chenf, Yen-Fu, Lee, Ting-Ting, Hsieh, Pei-Yun, Rusnac, Domnita V., Lin, Sung-Ya, Elledge, Stephen J., Zheng, Ning, Yen, Hsueh-Chi S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145449/
https://ncbi.nlm.nih.gov/pubmed/29775578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.006
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