C-terminal end-directed protein elimination by CRL2 ubiquitin ligases

The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant proteins. How miscellaneous defective proteins are specifically eliminated and which molecular characteristics direct them for removal are fundamental questions. We reveal a mechanism, D...

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Pubblicato in:Mol Cell
Autori principali: Lin, Hsiu-Chuan, Yehf, Chi-Wei, Chenf, Yen-Fu, Lee, Ting-Ting, Hsieh, Pei-Yun, Rusnac, Domnita V., Lin, Sung-Ya, Elledge, Stephen J., Zheng, Ning, Yen, Hsueh-Chi S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145449/
https://ncbi.nlm.nih.gov/pubmed/29775578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.006
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