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CRL2 Aids Elimination of Truncated Selenoproteins Produced by Failed UGA/Sec Decoding
Selenocysteine (Sec) is translated from the codon UGA, typically a termination signal. Codon duality extends the genetic code; coexistence of two competing UGA-decoding mechanisms, however, immediately compromises proteome fidelity. Selenium availability tunes reassignment of UGA to Sec. We report a...
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| Publicado no: | Science |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4766860/ https://ncbi.nlm.nih.gov/pubmed/26138980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab0515 |
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