The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

BACKGROUND: Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer’s disease (AD). Tau pathology correlates with cognitive decline in AD and follows a stereotypical anatomical course; several recent studie...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Hopp, Sarah C., Lin, Yang, Oakley, Derek, Roe, Allyson D., DeVos, Sarah L., Hanlon, David, Hyman, Bradley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145371/
https://ncbi.nlm.nih.gov/pubmed/30227881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1309-z
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