Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study

OBJECTIVE: This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to th...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Sandborn, William J, Lee, Scott D, Tarabar, Dino, Louis, Edouard, Klopocka, Maria, Klaus, Jochen, Reinisch, Walter, Hébuterne, Xavier, Park, Dong-Il, Schreiber, Stefan, Nayak, Satyaprakash, Ahmad, Alaa, Banerjee, Anindita, Brown, Lisa S, Cataldi, Fabio, Gorelick, Kenneth J, Cheng, John B, Hassan-Zahraee, Mina, Clare, Robert, D’Haens, Geert R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145284/
https://ncbi.nlm.nih.gov/pubmed/28982740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-313457
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