Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease

OBJECTIVE: To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn’s disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody. METHODS: In this Phase 2, randomised, double-blind, controlled stud...

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Detalhes bibliográficos
Publicado no:J Crohns Colitis
Main Authors: Hassan-Zahraee, Mina, Banerjee, Anindita, Cheng, John B, Zhang, Weidong, Ahmad, Alaa, Page, Karen, von Schack, David, Zhang, Baohong, Martin, Steven W, Nayak, Satyaprakash, Reddy, Padma, Xi, Li, Neubert, Hendrik, Fernandez Ocana, Mireia, Gorelick, Ken, Clare, Robert, Vincent, Michael, Cataldi, Fabio, Hung, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881777/
https://ncbi.nlm.nih.gov/pubmed/28961803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjx121
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