Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease

OBJECTIVE: To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn’s disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody. METHODS: In this Phase 2, randomised, double-blind, controlled stud...

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Detaylı Bibliyografya
Yayımlandı:J Crohns Colitis
Asıl Yazarlar: Hassan-Zahraee, Mina, Banerjee, Anindita, Cheng, John B, Zhang, Weidong, Ahmad, Alaa, Page, Karen, von Schack, David, Zhang, Baohong, Martin, Steven W, Nayak, Satyaprakash, Reddy, Padma, Xi, Li, Neubert, Hendrik, Fernandez Ocana, Mireia, Gorelick, Ken, Clare, Robert, Vincent, Michael, Cataldi, Fabio, Hung, Kenneth
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881777/
https://ncbi.nlm.nih.gov/pubmed/28961803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjx121
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