Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn’s Disease: Report of the TOSCA Study

BACKGROUND AND AIMS: Progressive multifocal leukoencephalopathy [PML], a brain infection associated with anti-integrin drugs that inhibit lymphocyte translocation from bloodstream to tissue, can be fatal. Decreased central nervous system [CNS] immune surveillance leading to this infection has been r...

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Publicado en:J Crohns Colitis
Main Authors: D’Haens, Geert, Vermeire, Séverine, Vogelsang, Harald, Allez, Matthieu, Desreumaux, Pierre, Van Gossum, Andre, Sandborn, William J, Baumgart, Daniel C, Ransohoff, Richard M, Comer, Gail M, Ahmad, Alaa, Cataldi, Fabio, Cheng, John, Clare, Robert, Gorelick, Kenneth J, Kaminski, Annamarie, Pradhan, Vivek, Rivers, Sunday, Sikpi, Matthew O, Zhang, Yanhua, Hassan-Zahraee, Mina, Reinisch, Walter, Stuve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881743/
https://ncbi.nlm.nih.gov/pubmed/28961770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjx128
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