mRNAs are sorted for export or degradation before passing through nuclear speckles

A significant fraction of mRNAs are degraded by the nuclear exosome in normal cells. Here, we studied where and when these exosome target mRNAs are sorted away from properly exported ones in the cells. We show that upon exosome inactivation, polyA RNAs are apparently accumulated in nuclear foci that...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Fan, Jing, Kuai, Bin, Wang, Ke, Wang, Lantian, Wang, Yimin, Wu, Xudong, Chi, Binkai, Li, Guohui, Cheng, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144872/
https://ncbi.nlm.nih.gov/pubmed/30032211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky650
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