mRNAs are sorted for export or degradation before passing through nuclear speckles

A significant fraction of mRNAs are degraded by the nuclear exosome in normal cells. Here, we studied where and when these exosome target mRNAs are sorted away from properly exported ones in the cells. We show that upon exosome inactivation, polyA RNAs are apparently accumulated in nuclear foci that...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Fan, Jing, Kuai, Bin, Wang, Ke, Wang, Lantian, Wang, Yimin, Wu, Xudong, Chi, Binkai, Li, Guohui, Cheng, Hong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2018
Gaiak:
Molecular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144872/
https://ncbi.nlm.nih.gov/pubmed/30032211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky650
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