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mRNAs are sorted for export or degradation before passing through nuclear speckles
A significant fraction of mRNAs are degraded by the nuclear exosome in normal cells. Here, we studied where and when these exosome target mRNAs are sorted away from properly exported ones in the cells. We show that upon exosome inactivation, polyA RNAs are apparently accumulated in nuclear foci that...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6144872/ https://ncbi.nlm.nih.gov/pubmed/30032211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky650 |
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