mRNAs are sorted for export or degradation before passing through nuclear speckles

A significant fraction of mRNAs are degraded by the nuclear exosome in normal cells. Here, we studied where and when these exosome target mRNAs are sorted away from properly exported ones in the cells. We show that upon exosome inactivation, polyA RNAs are apparently accumulated in nuclear foci that...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Fan, Jing, Kuai, Bin, Wang, Ke, Wang, Lantian, Wang, Yimin, Wu, Xudong, Chi, Binkai, Li, Guohui, Cheng, Hong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144872/
https://ncbi.nlm.nih.gov/pubmed/30032211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky650
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