Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export

The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome‐mediated degradation of these RNAs require...

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Publicado en:EMBO J
Autores principales: Fan, Jing, Kuai, Bin, Wu, Guifen, Wu, Xudong, Chi, Binkai, Wang, Lantian, Wang, Ke, Shi, Zhubing, Zhang, Heng, Chen, She, He, Zhisong, Wang, Siyuan, Zhou, Zhaocai, Li, Guohui, Cheng, Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623860/
https://ncbi.nlm.nih.gov/pubmed/28801509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696139
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