Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export

The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome‐mediated degradation of these RNAs require...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Fan, Jing, Kuai, Bin, Wu, Guifen, Wu, Xudong, Chi, Binkai, Wang, Lantian, Wang, Ke, Shi, Zhubing, Zhang, Heng, Chen, She, He, Zhisong, Wang, Siyuan, Zhou, Zhaocai, Li, Guohui, Cheng, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623860/
https://ncbi.nlm.nih.gov/pubmed/28801509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696139
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