E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form

According to the traditional view, GTPases act as molecular switches, which cycle between distinct ‘on’ and ‘off’ conformations bound to GTP and GDP, respectively. Translation elongation factor EF-Tu is a GTPase essential for prokaryotic protein synthesis. In its GTP-bound form, EF-Tu delivers amino...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Johansen, Jesper S, Kavaliauskas, Darius, Pfeil, Shawn H, Blaise, Mickaël, Cooperman, Barry S, Goldman, Yale E, Thirup, Søren S, Knudsen, Charlotte R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144822/
https://ncbi.nlm.nih.gov/pubmed/30107565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky697
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