Study protocol for the MEXiletine hydrochloride administration trial: a placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS)

INTRODUCTION: Spinal and bulbar muscular atrophy (SBMA) is a slowly progressive neuromuscular disease. Cold exposure often leads to worsening of motor symptoms including paresis. Although mexiletine hydrochloride administration has been shown to be effective for the treatment of several muscular dis...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Yamada, Shinichiro, Hashizume, Atsushi, Hijikata, Yasuhiro, Inagaki, Tomonori, Ito, Daisuke, Kinoshita, Fumie, Nakatochi, Masahiro, Kobayashi, Yumiko, Hirakawa, Akihiro, Nakamura, Tomohiko, Katsuno, Masahisa
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144396/
https://ncbi.nlm.nih.gov/pubmed/30206090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2018-023041
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