P04.62 The oncometabolite R-2-Hydroxyglutarate suppresses the innate immune microenvironment of IDH1-mutated gliomas via aryl hydrocarbon receptor signaling

BACKGROUND: IDH1-mutated gliomas are associated with less abundant and phenotypically skewed innate and adaptive immune cell infiltrates compared to IDH1 wild-type tumors. Despite this, the most frequent mutation - IDH1R132H - represents a clonal shared neoantigen and mutations in IDH are associated...

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Publicado en:Neuro Oncol
Autores principales: Friedrich, M, Bunse, L, Bunse, T, Green, E, Kessler, T, Pusch, S, Sanghvi, K, Carretero, R, Gutcher, I, von Deimling, A, Wick, W, Platten, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Poster Presentations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6144293/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy139.296
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