Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to un...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bridgford, Jessica L., Xie, Stanley C., Cobbold, Simon A., Pasaje, Charisse Flerida A., Herrmann, Susann, Yang, Tuo, Gillett, David L., Dick, Lawrence R., Ralph, Stuart A., Dogovski, Con, Spillman, Natalie J., Tilley, Leann
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143634/
https://ncbi.nlm.nih.gov/pubmed/30228310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06221-1
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