Increased mortality in CD43-deficient mice during sepsis

CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43(-/-) mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3+ Treg, and T cell apoptosis. However, the role of CD43 during sepsis has never been tested. Thus, we inter...

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Publicado en:PLoS One
Autores principales: Fay, Katherine T., Chihade, Deena B., Chen, Ching-Wen, Klingensmith, Nathan J., Lyons, John D., Ramonell, Kimberly, Liang, Zhe, Coopersmith, Craig M., Ford, Mandy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143188/
https://ncbi.nlm.nih.gov/pubmed/30226896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202656
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