CXCR4 blockade decreases CD4(+) T cell exhaustion and improves survival in a murine model of polymicrobial sepsis

Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4 is a chemokine receptor that, following ligation...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ramonell, Kimberly M., Zhang, Wenxiao, Hadley, Annette, Chen, Ching-wen, Fay, Katherine T., Lyons, John D., Klingensmith, Nathan J., McConnell, Kevin W., Coopersmith, Craig M., Ford, Mandy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726761/
https://ncbi.nlm.nih.gov/pubmed/29232699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188882
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