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Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood

Cannabis use is typically initiated during adolescence and is a significant risk factor for the development of cocaine use in adulthood. However, no preclinical studies have examined the effects of adolescent cannabinoid exposure on cocaine dependence in adulthood using the escalation model of cocai...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Kononoff, Jenni, Melas, Philippe A., Kallupi, Marsida, de Guglielmo, Giordano, Kimbrough, Adam, Scherma, Maria, Fadda, Paola, Kandel, Denise B., Kandel, Eric R., George, Olivier
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141462/
https://ncbi.nlm.nih.gov/pubmed/30224774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31921-5
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