Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood

Cannabis use is typically initiated during adolescence and is a significant risk factor for the development of cocaine use in adulthood. However, no preclinical studies have examined the effects of adolescent cannabinoid exposure on cocaine dependence in adulthood using the escalation model of cocai...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kononoff, Jenni, Melas, Philippe A., Kallupi, Marsida, de Guglielmo, Giordano, Kimbrough, Adam, Scherma, Maria, Fadda, Paola, Kandel, Denise B., Kandel, Eric R., George, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141462/
https://ncbi.nlm.nih.gov/pubmed/30224774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31921-5
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