Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats

GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some mental disorders, but behavioral studies have no...

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Dettagli Bibliografici
Pubblicato in:eNeuro
Autori principali: Kononoff, Jenni, Kallupi, Marsida, Kimbrough, Adam, Conlisk, Dana, de Guglielmo, Giordano, George, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2018
Soggetti:
New Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027959/
https://ncbi.nlm.nih.gov/pubmed/29971251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0153-18.2018
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