Transcriptional targeting of oncogene addiction in medullary thyroid cancer

Metastatic medullary thyroid cancer (MTC) is incurable and FDA-approved kinase inhibitors that include oncogenic RET as a target do not result in complete responses. Association studies of human MTCs and murine models suggest that the CDK/RB pathway may be an alternative target. The objective of thi...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Valenciaga, Anisley, Saji, Motoyasu, Yu, Lianbo, Zhang, Xiaoli, Bumrah, Ceimoani, Yilmaz, Ayse S., Knippler, Christina M., Miles, Wayne, Giordano, Thomas J., Cote, Gilbert J., Ringel, Matthew D.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141185/
https://ncbi.nlm.nih.gov/pubmed/30135308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122225
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