Subcellular origin of mitochondrial DNA deletions in human skeletal muscle

OBJECTIVE: In patients with mitochondrial DNA (mtDNA) maintenance disorders and with aging, mtDNA deletions sporadically form and clonally expand within individual muscle fibers, causing respiratory chain deficiency. This study aimed to identify the sub‐cellular origin and potential mechanisms under...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Vincent, Amy E., Rosa, Hannah S., Pabis, Kamil, Lawless, Conor, Chen, Chun, Grünewald, Anne, Rygiel, Karolina A., Rocha, Mariana C., Reeve, Amy K., Falkous, Gavin, Perissi, Valentina, White, Kathryn, Davey, Tracey, Petrof, Basil J., Sayer, Avan A., Cooper, Cyrus, Deehan, David, Taylor, Robert W., Turnbull, Doug M., Picard, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141001/
https://ncbi.nlm.nih.gov/pubmed/30014514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25288
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