Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating

The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive the unfolding and translocation of substrates into the proteolytic 20S core particle for degradation....

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Publicado no:Cell Rep
Main Authors: Eisele, Markus R., Reed, Randi G., Rudack, Till, Schweitzer, Andreas, Beck, Florian, Nagy, Istvan, Pfeifer, Gunter, Plitzko, Jürgen M., Baumeister, Wolfgang, Tomko, Robert J., Sakata, Eri
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140342/
https://ncbi.nlm.nih.gov/pubmed/30067984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.004
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