Structural insights into the functional cycle of the ATPase module of the 26S proteasome

In eukaryotic cells, the ubiquitin–proteasome system (UPS) is responsible for the regulated degradation of intracellular proteins. The 26S holocomplex comprises the core particle (CP), where proteolysis takes place, and one or two regulatory particles (RPs). The base of the RP is formed by a heteroh...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wehmer, Marc, Rudack, Till, Beck, Florian, Aufderheide, Antje, Pfeifer, Günter, Plitzko, Jürgen M., Förster, Friedrich, Schulten, Klaus, Baumeister, Wolfgang, Sakata, Eri
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307450/
https://ncbi.nlm.nih.gov/pubmed/28115689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621129114
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