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Defective mucin-type glycosylation on α-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases

Deficiency in subunits of the conserved oligomeric Golgi (COG) complex results in pleiotropic defects in glycosylation and causes congenital disorders in humans. Insight regarding the functional consequences of this defective glycosylation and the identity of specific glycoproteins affected is lacki...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Yu, Seok-Ho, Zhao, Peng, Prabhakar, Pradeep K., Sun, Tiantian, Beedle, Aaron, Boons, Geert-Jan, Moremen, Kelley W., Wells, Lance, Steet, Richard
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139567/
https://ncbi.nlm.nih.gov/pubmed/30049793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003014
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