Protein O-Linked Mannose β-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of α-Dystroglycan

Disruption of the O-mannosylation pathway involved in functional glycosylation of α-dystroglycan gives rise to congenital muscular dystrophies. Protein O-linked mannose β-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) catalyzes the first step toward the functional matriglycan structure on α-dystrog...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Halmo, Stephanie M., Singh, Danish, Patel, Sneha, Wang, Shuo, Edlin, Melanie, Boons, Geert-Jan, Moremen, Kelley W., Live, David, Wells, Lance
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313085/
https://ncbi.nlm.nih.gov/pubmed/27932460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764712
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