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Plasminogen activation triggers transthyretin amyloidogenesis in vitro

Systemic amyloidosis is a usually fatal disease caused by extracellular accumulation of abnormal protein fibers, amyloid fibrils, derived by misfolding and aggregation of soluble globular plasma protein precursors. Both WT and genetic variants of the normal plasma protein transthyretin (TTR) form am...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139548/
https://ncbi.nlm.nih.gov/pubmed/30018138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003990
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