Plasminogen activation triggers transthyretin amyloidogenesis in vitro

Systemic amyloidosis is a usually fatal disease caused by extracellular accumulation of abnormal protein fibers, amyloid fibrils, derived by misfolding and aggregation of soluble globular plasma protein precursors. Both WT and genetic variants of the normal plasma protein transthyretin (TTR) form am...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Mangione, P. Patrizia, Verona, Guglielmo, Corazza, Alessandra, Marcoux, Julien, Canetti, Diana, Giorgetti, Sofia, Raimondi, Sara, Stoppini, Monica, Esposito, Marilena, Relini, Annalisa, Canale, Claudio, Valli, Maurizia, Marchese, Loredana, Faravelli, Giulia, Obici, Laura, Hawkins, Philip N., Taylor, Graham W., Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139548/
https://ncbi.nlm.nih.gov/pubmed/30018138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003990
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