Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease

Autosomal-dominant polycystic kidney disease (ADPKD) is a very common genetic disease leading to renal failure. Numerous aberrantly regulated signaling pathways have been identified as promising molecular drug targets for ADPKD therapy. In rodent models, many small-molecule drugs against such target...

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Udgivet i:Am J Physiol Renal Physiol
Main Authors: Kipp, Kevin R., Kruger, Samantha L., Schimmel, Margaret F., Parker, Nikki, Shillingford, Jonathan M., Leamon, Christopher P., Weimbs, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139519/
https://ncbi.nlm.nih.gov/pubmed/29717938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00057.2018
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