Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to fibroblast activation, extracellular matrix remodeling, and subsequently loss of...

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Опубликовано в: :Respir Res
Главные авторы: Lehmann, Mareike, Buhl, Lara, Alsafadi, Hani N., Klee, Stephan, Hermann, Sarah, Mutze, Kathrin, Ota, Chiharu, Lindner, Michael, Behr, Jürgen, Hilgendorff, Anne, Wagner, Darcy E., Königshoff, Melanie
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138909/
https://ncbi.nlm.nih.gov/pubmed/30219058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0876-y
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