Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as pathogenic drivers. The lung alveolar epithelium represents...

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Detalhes bibliográficos
Publicado no:Eur Respir J
Main Authors: Lehmann, Mareike, Korfei, Martina, Mutze, Kathrin, Klee, Stephan, Skronska-Wasek, Wioletta, Alsafadi, Hani N., Ota, Chiharu, Costa, Rita, Schiller, Herbert B., Lindner, Michael, Wagner, Darcy E., Günther, Andreas, Königshoff, Melanie
Formato: Artigo
Idioma:Inglês
Publicado em: European Respiratory Society 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593348/
https://ncbi.nlm.nih.gov/pubmed/28775044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02367-2016
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