Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

The GTPase Rab11 plays key roles in receptor recycling, oogenesis, autophagosome formation, and ciliogenesis. However, investigating Rab11 regulation has been hindered by limited molecular detail describing activation by cognate guanine nucleotide exchange factors (GEFs). Here, we present the struct...

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Udgivet i:Nat Commun
Main Authors: Jenkins, Meredith L., Margaria, Jean Piero, Stariha, Jordan T. B., Hoffmann, Reece M., McPhail, Jacob A., Hamelin, David J., Boulanger, Martin J., Hirsch, Emilio, Burke, John E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138693/
https://ncbi.nlm.nih.gov/pubmed/30217979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06196-z
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