A Novel 3-dimensional High Throughput Screening Approach Identifies Inducers of a Mutant KRAS Selective Lethal Phenotype

The RAS proteins are the most frequently mutated oncogenes in cancer, with highest frequency found in pancreatic, lung, and colon tumors. Moreover, the activity of RAS is required for the proliferation and/or survival of these tumor cells and thus represents a high-value target for therapeutic devel...

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Udgivet i:Oncogene
Main Authors: Kota, Smitha, Hou, Shurong, Guerrant, William, Madoux, Franck, Troutman, Scott, Fernandez-Vega, Virneliz, Alekseeva, Nina, Madala, Neeharika, Scampavia, Louis, Kissil, Joseph, Spicer, Timothy P.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138545/
https://ncbi.nlm.nih.gov/pubmed/29743592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0257-5
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