Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

Traditional high-throughput drug screening in oncology routinely relies on two-dimensional (2D) cell models, which inadequately recapitulate the physiologic context of cancer. Three-dimensional (3D) cell models are thought to better mimic the complexity of in vivo tumors. Numerous methods to culture...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Hou, Shurong, Tiriac, Hervé, Sridharan, Banu Priya, Scampavia, Louis, Madoux, Franck, Seldin, Jan, Souza, Glauco R., Watson, Donald, Tuveson, David, Spicer, Timothy P.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013403/
https://ncbi.nlm.nih.gov/pubmed/29673279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218766842
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