CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling

Multi‐subunit cullin‐RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4(AMBRA) (1) (CRL substrat...

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Publicat a:EMBO J
Autors principals: Chen, Si‐Han, Jang, Gwendolyn M, Hüttenhain, Ruth, Gordon, David E, Du, Dan, Newton, Billy W, Johnson, Jeffrey R, Hiatt, Joseph, Hultquist, Judd F, Johnson, Tasha L, Liu, Yi‐Liang, Burton, Lily A, Ye, Jordan, Reichermeier, Kurt M, Stroud, Robert M, Marson, Alexander, Debnath, Jayanta, Gross, John D, Krogan, Nevan J
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138441/
https://ncbi.nlm.nih.gov/pubmed/30166453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797508
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