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CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling
Multi‐subunit cullin‐RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4(AMBRA) (1) (CRL substrat...
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| Gepubliceerd in: | EMBO J |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
John Wiley and Sons Inc.
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6138441/ https://ncbi.nlm.nih.gov/pubmed/30166453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797508 |
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