CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling

Multi‐subunit cullin‐RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4(AMBRA) (1) (CRL substrat...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Chen, Si‐Han, Jang, Gwendolyn M, Hüttenhain, Ruth, Gordon, David E, Du, Dan, Newton, Billy W, Johnson, Jeffrey R, Hiatt, Joseph, Hultquist, Judd F, Johnson, Tasha L, Liu, Yi‐Liang, Burton, Lily A, Ye, Jordan, Reichermeier, Kurt M, Stroud, Robert M, Marson, Alexander, Debnath, Jayanta, Gross, John D, Krogan, Nevan J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138441/
https://ncbi.nlm.nih.gov/pubmed/30166453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797508
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