Quantitative contribution of rs75017182 to dihydropyrimidine dehydrogenase mRNA splicing and enzyme activity

Dihydropyrimidine dehydrogenase (DPD; DPYD gene) variants have emerged as reliable predictors of adverse toxicity to the chemotherapy agent 5-fluorouracil (5-FU). The intronic DPYD variant rs75017182 has been recently suggested to promote alternative splicing of DPYD. However, both the extent of alt...

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Pubblicato in:Clin Pharmacol Ther
Autori principali: Nie, Qian, Shrestha, Shikshya, Tapper, Erin E., Trogstad-Isaacson, Colbren S., Bouchonville, Kelly J., Lee, Adam M., Wu, Rentian, Jerde, Calvin R., Wang, Zhiquan, Kubica, Phillip A., Offer, Steven M., Diasio, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138243/
https://ncbi.nlm.nih.gov/pubmed/28295243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.685
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